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Low Acetylcholine During Early Sleep s Crucial for Motor Memory Consolidation
Başlık:
Low Acetylcholine During Early Sleep s Crucial for Motor Memory Consolidation
Yazar:
Qandeel, author.
ISBN:
9780438019256
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (74 pages)
Genel Not:
Source: Masters Abstracts International, Volume: 57-06M(E).
Advisors: Majid Mohajerani.
Özet:
There has been no evidence that manipulation of acetylcholine levels in association with sleep treatments can influence motor memory storage. The purpose of the present study was to investigate a potential relationship between motor memory and acetylcholine activity during early part of sleep. We propose that during the early phase of sleep, characterized by slow wave electroencephalographic activity and reduced cholinergic tone, a downscaling of overall synaptic strength happens that improves signal-to-noise ratio and facilitates motor memory consolidation. Therefore, altering acetylcholine levels during early sleep would disrupt the consolidation of motor memories. To test this hypothesis, 93 C57 Black/6J and 17 transgenic (CAG-hM4Di x Chat-Cre) adult mice were trained for motor tasks either rotarod or skilled-forelimb reach. Immediately after motor training, ACh was either increased or decreased in the subsequent post-learning sleep. Retesting showed that increasing ACh in post-learning sleep impaired motor memory consolidation however, decreasing ACh levels did not have an effect. Furthermore, a relatively larger involvement of muscarinic ACh receptors compared to nicotinic ones was observed in motor memory consolidation. Home-cage filming suggested that mice in both control and experimental conditions had similar sleep cycles while electrophysiology showed that slow wave power in early sleep was reduced with increasing ACh levels. These results suggest that motor memories are consolidated during slow wave sleep when cholinergic levels are low. The early phase of sleep therefore may contribute to motor memory consolidation by providing a homeostatic state characterized by slow wave activity and reduced ACh.
Notlar:
School code: 1112
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(694369.1) | 694369-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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