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Sin3b is Not Required for Normal Cell Proliferation in D. Rerio
Başlık:
Sin3b is Not Required for Normal Cell Proliferation in D. Rerio
Yazar:
Salerno-Eichenholz, Ryan, author.
ISBN:
9780438129757
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (26 pages)
Genel Not:
Source: Masters Abstracts International, Volume: 57-06M(E).
Advisors: Howard Sirotkin Committee members: Benjamin Martin.
Özet:
Zebrafish sin3b mutants survive to adulthood but are small in size. Sin3b is linked to cell cycle checkpoint activity through interactions with proteins in the Rb and E2F pathways. Therefore, I investigated whether defects in cellular proliferation and growth during embryonic and larval stages contributed to the size alternations in sin3b mutants. To accomplish this, I took measurements of the sin3b mutant larva and used immunohistochemistry to determine the average numbers of actively dividing cells. I also tested the abilities of these embryos to survive genotoxic environments, based on the role a mammalian paralogue protein (mSin3a) plays in relieving genotoxic stress. When compared with identical measurements of unaltered fish embryos of the same age, no statistically significant difference appeared in any of these assays, though the data indicates that larger studies or studies combining null Sin3b with other related null proteins may reveal effects on cell proliferation.
Notlar:
School code: 0771
Konu Başlığı:
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(689732.1) | 689732-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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