![](/client/images/blank.gif)
Eylem Seç
![CD4+ T Helper 17 Cells in Protective Immunity Versus Immunopathology in Trypanosoma cruzi Parasite Infection için kapak resmi CD4+ T Helper 17 Cells in Protective Immunity Versus Immunopathology in Trypanosoma cruzi Parasite Infection için kapak resmi](/client/assets/cf6e192b74af2810/ctx/images/no_image.png)
CD4+ T Helper 17 Cells in Protective Immunity Versus Immunopathology in Trypanosoma cruzi Parasite Infection
Başlık:
CD4+ T Helper 17 Cells in Protective Immunity Versus Immunopathology in Trypanosoma cruzi Parasite Infection
Yazar:
Cai, Catherine W., author.
ISBN:
9780438128002
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (104 pages)
Genel Not:
Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B.
Advisors: Daniel F. Hoft Committee members: Richard J. DiPaolo; Lynda A. Morrison; Guangyong Peng; Ryan M. Teague.
Özet:
Trypanosoma cruzi is a protozoan parasite that establishes chronic infections in humans, causing Chagas disease, a Neglected Tropical Disease endemic throughout Latin America. 1 in 3 chronically infected people will ultimately develop life-threatening cardiac or gastrointestinal disease. An effective vaccine that induces protective immune responses against this pathogen could reduce the number of new infections or even prevent the progression of disease in those already infected.
Although CD4+ Th1 cells are known to protect against T. cruzi infection, the role of CD4+ Th17 cells was previously undefined. Th17 cells are involved in host defense against some extracellular species, but their role in intracellular immunity is not well supported. Using a T cell receptor transgenic mouse, we generated parasite-specific Th1 and Th17 cells and used these cells for both in vivo and in vitro experiments. We demonstrate using adoptive cell transfer experiments that Th17 cells can provide robust protection against both systemic and mucosal T. cruzi infections through distinct mechanisms. In systemic infections, Th17 cells provide more potent helper effects than Th1 cells for the activation and proliferation of antigen-specific CD8+ T cells via the secretion of IL-21. In mucosal infections, Th17 cells provide direct protection for infected cells by secreting IL-17A, which induces NADPH oxidase for the generation of reactive oxygen species.
We further provide evidence that Th17 cells do not enhance cardiac disease compared to Th1 cells using longitudinal electrocardiogram monitoring of infected mice given Th1 or Th17 cells, and we demonstrate that Th17 cells can be induced endogenously via vaccination. Finally, we provide preliminary evidence that some of these mechanisms of protection against T. cruzi infection by Th17 cells may translate into humans.
This work identifies a strong protective effect of Th17 cells against both systemic and mucosal T. cruzi infections, and details the specific mechanisms required for Th17-mediated protection. These results have characterized novel functions of Th17 cells that will streamline the future development of effective human vaccines against T. cruzi and may provide important insights for other mucosally invasive infectious pathogens.
Notlar:
School code: 0193
Tüzel Kişi Ek Girişi:
Mevcut:*
Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(694076.1) | 694076-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
On Order
Liste seç
Bunu varsayılan liste yap.
Öğeler başarıyla eklendi
Öğeler eklenirken hata oldu. Lütfen tekrar deneyiniz.
:
Select An Item
Data usage warning: You will receive one text message for each title you selected.
Standard text messaging rates apply.