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Functional and Anatomical Relationships Between the Medial Precentral Cortex, Dorsal Striatum, and Head Direction Cell Circuitry
Başlık:
Functional and Anatomical Relationships Between the Medial Precentral Cortex, Dorsal Striatum, and Head Direction Cell Circuitry
Yazar:
Mehlman, Max L., author.
ISBN:
9780438005877
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (143 pages)
Genel Not:
Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Advisors: Jeffrey S. Taube Committee members: David J. Bucci; Douglas A. Nitz; Matthijs A. van der Meer.
Özet:
Head direction (HD) cells fire as a function of the animal's directional heading within its environment, providing an internal sense of direction used for navigation. In rodents, HD cells are located primarily within the limbic system in the interconnected structures that form the canonical limbic HD circuit. Interestingly, small populations of HD cells have been reported outside of this circuit in two extralimbic areas: the medial precentral cortex (PrCM) and dorsal striatum (DS). We performed a series of electrophysiological and neuroanatomical studies in rats to examine functional and anatomical relationships between the PrCM, DS, and limbic HD circuit.
We first recorded HD cells in the PrCM and DS; these extralimbic HD cells displayed characteristics mirroring those of limbic HD cells recorded in the anterodorsal thalamic nucleus (ADN), a central node in the limbic HD circuit. We then recorded PrCM and DS activity in animals with ADN lesions, a manipulation that disrupts limbic HD circuit output. These lesions eliminated HD cell activity in the PrCM and DS. Finally, we recorded ADN activity in animals with combined PrCM and DS lesions; these lesions did not affect the activity of ADN HD cells. This overall pattern of results indicates that output from the limbic system drives HD cell activity in the PrCM and DS, but these extralimbic areas do not provide critical input or feedback to limbic HD cells.
Next, we performed tracing experiments to identify the underlying anatomical pathways that could facilitate communication between the PrCM, DS, and limbic HD circuit. Retrograde tracing revealed that the PrCM and DS each receive direct input from multiple structures in the limbic HD circuit. These projections preferentially target and converge within the portions of the PrCM and DS in which we recorded HD cells. Anterograde tracing revealed that the PrCM and DS each project back to the limbic HD circuit via an indirect subcortical pathway.
Collectively, our findings represent an important step forward in understanding spatial processing circuitry beyond the limbic system, and provide a valuable foundation for future research examining the PrCM and DS in the context of navigation and spatial cognition.
Notlar:
School code: 0059
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(681839.1) | 681839-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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