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Neural Mechanisms Mediating Social Influences on Drinking Decisions in Women with AUD
Başlık:
Neural Mechanisms Mediating Social Influences on Drinking Decisions in Women with AUD
Yazar:
Manfredi, Emmanuelle Isabella, author. (orcid)0000-0003-4776-1256
ISBN:
9780438029033
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (43 pages)
Genel Not:
Source: Masters Abstracts International, Volume: 57-06M(E).
Advisors: Thomas W. James Committee members: Anne C. Krendl; Richard J. Viken.
Özet:
Alcohol use disorder (AUD) is a significant public health burden that disproportionately affects women. Although social factors are the strongest mediators of drinking behavior, and young adults are three times more likely than the general population to suffer from AUD, little research exists that connects neural correlates of social influence on decisions-to-drink in young adult women. Interventions for AUD are also shown to have low success in preventing relapse; suggesting new intervention methods are necessary. This research aims to provide insightful data on social influence on drinking decisions and BOLD signal in women with AUD to establish a framework towards improved AUD treatment. Behavioral data of the decisions-to-drink task were analyzed with repeated-measures ANOVA and fMRI data were analyzed using BrainVoyager(TM) software. Across all conditions, AUD women showed greater endorsement for alcohol. Interestingly, AUD women endorsed drinking most when the female social group was not drinking. Imaging data showed greater activation in regions of the "social brain," including the ventral medial prefrontal cortex (vmPFC) for social scenes than non-social scenes. Although the social brain was involved equally for both controls and AUDs, the vmPFC was more activated during social context-mediated drinking decisions for AUDs. Conversely, regions involved in cognitive control, such as the dorsolateral prefrontal cortex (dlPFC), showed greater activation in controls for social drinking decisions. AUDs decisions-to-drink after presentation of alcohol cues and high-risk scenarios in social context was most impaired when the social group was composed of all females not drinking and when cognitive control was decreased and reward neural activation was increased. Manipulation of social context revealed differential effects in behavioral and neural measures for women with AUD. These differences allude to factors that could be targeted in the development of new interventions. Understanding the social contexts that precede sub-optimal decisions and the underlying neural mechanisms, especially in vulnerable populations, allows for the design of tailored and effective models and interventions.
Notlar:
School code: 0093
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(692313.1) | 692313-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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