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Orexins via Their Receptors Influence Anxious Behavior during Social Stress
Başlık:
Orexins via Their Receptors Influence Anxious Behavior during Social Stress
Yazar:
Staton, Clarissa Dru, author.
ISBN:
9780438121737
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (63 pages)
Genel Not:
Source: Masters Abstracts International, Volume: 57-06M(E).
Advisors: Cliff H. Summers Committee members: Kenneth J. Renner; Patrick J. Ronan.
Özet:
Anxiety, social stress, and depression are prominent and poorly understood disorders that affect a large population. Orexins are a set of neuropeptides that have been known to play significant roles in stress and anxiety responses. There is evidence that orexin's two receptors, Orx1 and Orx 2, have opposing effects in certain brain regions, with Orx1 having anxiogenic properties. New animal models are arising that better address these disorders, including the Stress-Alternatives Model (SAM), which produces social stress in the form of social aggression. In this model, mice have the decision to escape (Escape), or remain (Stay) in the social aggression. A gradient of anxiety is produced based on animal responses, where familiar escape causes the least anxiety and staying with social aggression causes the most anxiety, as determined using other accepted methods for measuring anxiety. I hypothesized that antagonism of Orx2 receptors via intracerebral ventricular (icv) injections would promote anxiety, while agonism of Orx 2 receptors would inhibit anxiety. My results indicate that the anxiolytic Escape phenotype was blocked with Orx2 antagonism, while anxiogenic Stay phenotype was promoted. I also demonstrated that anxious behaviors such as freezing time (both contextual and cued) and startle responses were higher in animals exhibiting the Stay phenotype and were reduced with Orx2 agonism. Anxiolytic responses, such as time spent attentive to the escape route, were significantly diminished in mice exhibiting the Stay phenotype but were rescued and amplified by Orx2 agonism. I also sought to further validate the SAM by comparing SAM results with the well-known and accepted Social Interaction/Preference (SIP) test and found that resiliency to social stress was decreased via Orx2 antagonism and increased via Orx2 agonism. Together these results indicate an overall anxiolytic and anti-depressive effect of Orx2 receptors when administered icv.
Notlar:
School code: 0203
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(694365.1) | 694365-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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