Eylem Seç
Metal-induced oxidative stress in human fibroblasts: A role in cellular ageing = O PAPEL DO STRESSE OXIDATIVO INDUZIDO POR METAIS NO ENVELHECIMENTO CELULAR
Başlık:
Metal-induced oxidative stress in human fibroblasts: A role in cellular ageing = O PAPEL DO STRESSE OXIDATIVO INDUZIDO POR METAIS NO ENVELHECIMENTO CELULAR
Yazar:
Silva, Liliana Raquel Casais de Matos, author.
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (123 pages)
Genel Not:
Source: Dissertation Abstracts International, Volume: 76-07C.
Özet:
Ageing became a major concern of modern societies due to its vast social and financial impact. Therefore, it has been widely investigated in an attempt to find strategies able to delay the age-related health deterioration and the establishment of diseases. In this setting, it is crucial to identify potential contributors and unravel their inherent molecular mechanisms implicated in the ageing process.
At the cellular level, it is characterized by the progressive accumulation of oxidatively damaged biomolecules that ultimately lead to cellular dysfunction. Among the conditions favoring the process may be the alterations on metal homeostasis that result in their increased levels or accumulation within cells and tissues, where they foster the generation of reactive oxygen species (ROS) that target biomolecules. In fact, enhanced copper levels were reported during ageing and in age-associated diseases such as type II diabetes, atherosclerosis and neurodegenerative disorders, further supporting the contribution of copper for oxidative stress and the overall age-related functional deterioration.
In vitro cellular models of senescence are essential to study molecular events during the ageing process. Stress-induced premature senescence (SIPS) models are frequently employed as they present various advantages when compared to the classical replicative senescence (RS) model: they are faster to obtain, easier to manipulate and exhibit a heterogeneous cellular response similar to the in vivo condition. The most frequently used SIPS inducer is hydrogen peroxide (H2O2), but other oxidative stress inducers may be successfully employed.
Based on copper ability to mediate the formation of free radicals, the current work reported, for the first time, that incubation of WI-38 fibroblasts with a subcytotoxic concentration of copper sulfate (CuSO4) induces SIPS. In fact, CuSO4-SIPS fibroblasts exhibit typical senescent phenotype features, including altered morphology, increased senescence-associated beta-galactosidase (SA âgal), cell proliferation inhibition and several senescence-associated genes and proteins upregulation.
Notlar:
School code: 5896
Konu Başlığı:
Tüzel Kişi Ek Girişi:
Mevcut:*
Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(678871.1) | 678871-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
On Order
Liste seç
Bunu varsayılan liste yap.
Öğeler başarıyla eklendi
Öğeler eklenirken hata oldu. Lütfen tekrar deneyiniz.
:
Select An Item
Data usage warning: You will receive one text message for each title you selected.
Standard text messaging rates apply.