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![Exploring the Relationship Between Cellular Senescence and DNA Polymerasebeta in Down Syndrome için kapak resmi Exploring the Relationship Between Cellular Senescence and DNA Polymerasebeta in Down Syndrome için kapak resmi](/client/assets/cf6e192b74af2810/ctx/images/no_image.png)
Exploring the Relationship Between Cellular Senescence and DNA Polymerasebeta in Down Syndrome
Başlık:
Exploring the Relationship Between Cellular Senescence and DNA Polymerasebeta in Down Syndrome
Yazar:
Pace, Brianna, author.
ISBN:
9780438030275
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (24 pages)
Genel Not:
Source: Masters Abstracts International, Volume: 57-06M(E).
Advisors: Diane Cress Committee members: AHMAD HEYDARI; MARY WIDTH.
Özet:
The goal of this paper is establish and evaluate the relationship between the accelerated aging and premature cellular senescence with the reduced DNA polymerasebeta observed in Down syndrome. Primary fibroblasts from Down syndrome individuals demonstrate greater SA-beta-Gal staining (4-fold increase, p<0.001), increased p16 transcript abundance (3-fold increase, p<0.01), and reduced HMGB1 nuclear localization (1.5-fold lower, p<0.01) when compared to primary fibroblast from non-Down syndrome fibroblasts. These biomarkers of senescence establish the premature aging expected in a Down syndrome individual. DNA polymerase beta (POLbeta) expression is significantly reduced in Down syndrome primary fibroblasts (53% decline, p<0.01). While we are unable to definitely state a direct causal link between DNA polymerasebeta reduction and the precocious aging present, it is demonstrated that DNA polymerasebeta plays a role.
Notlar:
School code: 0254
Tüzel Kişi Ek Girişi:
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(692781.1) | 692781-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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