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![Identification of Cav 3.2 T-Type Voltage Gated Calcium Channels as Key Mediators of Targeted Inhibition of Hepatocellular Carcinoma by Amplitude-Modulated Radiofrequency Electromagnetic Fieldselectromagnetic Fields için kapak resmi Identification of Cav 3.2 T-Type Voltage Gated Calcium Channels as Key Mediators of Targeted Inhibition of Hepatocellular Carcinoma by Amplitude-Modulated Radiofrequency Electromagnetic Fieldselectromagnetic Fields için kapak resmi](/client/assets/d79c3e4af2b6d196/ctx/images/no_image.png)
Identification of Cav 3.2 T-Type Voltage Gated Calcium Channels as Key Mediators of Targeted Inhibition of Hepatocellular Carcinoma by Amplitude-Modulated Radiofrequency Electromagnetic Fieldselectromagnetic Fields
Başlık:
Identification of Cav 3.2 T-Type Voltage Gated Calcium Channels as Key Mediators of Targeted Inhibition of Hepatocellular Carcinoma by Amplitude-Modulated Radiofrequency Electromagnetic Fieldselectromagnetic Fields
Yazar:
Jimenez, Hugo, author.
ISBN:
9780355986679
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (198 pages)
Genel Not:
Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Advisors: Boris C. Pasche Committee members: Carl F. Blackman; Waldemar Debinski; Glenn Lesser; Ravi Singh.
Özet:
Amplitude-modulated 27.12 MHz radiofrequency electromagnetic fields (AM RF EMF) delivered via a spoon-shaped antenna placed on the patient's tongue results in shrinkage of the primary and metastatic tumors in patients with advanced hepatocellular carcinoma (HCC). The mechanism by which AM RF EMF have direct antiproliferative effect cancer cells is largely unknown.
In order to deduce the unknown mechanism of action we have assessed the Specific Absorption Rate (SAR) level and distribution inside the human body. Additionally, we performed various in vitro and in vivo experiments that were exposed to HCC-specific AM RF EMF using systems replicating human exposure levels and treatment duration. The resulting data provided new insights into the mechanism of action of a novel systemic therapy.
Therefore, this dissertation will show that HCC-specific AM RF EMF's antiproliferative effects are mediated by Ca2+ influx through Cav3.2 T-type voltage-gated calcium channel (CACNA1H). This finding establishes a key functional role for Cav3.2 in control of HCC proliferation, and furthermore establishes this transmembrane protein complex as a main target for HCC-specific AM RF EMF.
Notlar:
School code: 0248
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(680230.1) | 680230-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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