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![The Association Between Cortisol and Objective and Subjective Reports of Activities of Daily Living in a Cohort of Older Adults with Depression için kapak resmi The Association Between Cortisol and Objective and Subjective Reports of Activities of Daily Living in a Cohort of Older Adults with Depression için kapak resmi](/client/assets/d79c3e4af2b6d196/ctx/images/no_image.png)
The Association Between Cortisol and Objective and Subjective Reports of Activities of Daily Living in a Cohort of Older Adults with Depression
Başlık:
The Association Between Cortisol and Objective and Subjective Reports of Activities of Daily Living in a Cohort of Older Adults with Depression
Yazar:
Shindel, Cydney, author.
ISBN:
9780438025134
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (151 pages)
Genel Not:
Source: Dissertation Abstracts International, Volume: 79-10(E), Section: A.
Advisors: Dolores Gallagher-Thompson Committee members: Jason Holland; Jamie Kent.
Özet:
Demographic trends in the United States demonstrate a rising older adult population. Depressive disorders manifest in a significant percentage of older adults across various settings. Late life depression can have serious cognitive and physical consequences that can ultimately impair older adults' quality of life. Cortisol is proposed to be a primary neurobiological avenue through which depression impacts health. Dysregulated cortisol in older individuals is associated with a number of disease states as well as neurodegeneration and executive dysfunction. These latter issues have been linked to impaired functional status (i.e., difficulty carrying out both simple and complex activities of daily living) in older adults. Notably, despite the fact that depression is associated with both excessive cortisol and functional impairment, there is highly limited research examining the direct relationship between cortisol and functional status in older adults with depression.
The present study examined the relationship between cortisol and functional status in a community sample of 51 older adults with depression. A primary goal of the study was also to assess the utility of a unique, observer-rated functional status measure, the Performance of Appointment Tasks Scale (PATS). It was hypothesized that greater cortisol dysregulation would be associated with more impaired functional status and that an observer-rated measure of functional status would be more closely correlated with cortisol levels than a self-report functional status measure.
Results from multiple hierarchical linear regressions provided support for both of the primary hypotheses. Individuals who had higher levels of cortisol also tended to demonstrate greater functional deficits and the PATS was significantly correlated with cortisol levels whereas the self-report measure was not. Exploratory analyses were run holding gender constant in lieu of depression severity. Doing so did not significantly alter the outcome of the model.
Findings from this study begin to fill the gap in research examining the relationship between cortisol and functional impairment in older adults. The results herein also provide preliminary support for the utility of the PATS. Lastly, these findings are in line with existing literature indicating that, in general, self-report measures tend to be less reliable than performance-based and observational functional status measures.
Notlar:
School code: 1569
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(677879.1) | 677879-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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