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Drug-drug interactions : scientific and regulatory perspectives
Başlık:
Drug-drug interactions : scientific and regulatory perspectives
Yazar:
Li, A. P.
ISBN:
9780080581354
9781281735546
9786611735548
Yayın Bilgileri:
San Diego, Calif. : Academic Press, ©1997.
Fiziksel Tanımlama:
1 online resource (xviii, 304 pages) : illustrations.
Seri:
Advances in pharmacology ; v. 43
Advances in pharmacology ; v. 43.
İçerik:
Overview : pharmacokinetic drug-drug interactions / Role of cytochrome P450 enzymes in drug-drug interactions / Liver as a target for chemical-chemical interactions / Application of human liver microsomes in metabolism-based drug-drug interactions : in vitro-in vivo correlations and the Abbott Laboratories experience / Primary hepatocyte cultures as an in vitro experimental model for the evaluation of pharmacokinetic drug-drug interactions / Liver slices as a model in drug metabolism / Use of cDNA-expressed human cytochrome P450 enzymes to study potential drug-drug interactions
Pharmacokinetics of drug interactions / Experimental models for evaluating enzyme induction potential of new drug candidates in animals and humans and a strategy for their use / Metabolic drug-drug interactions : perspective from FDA medical and clinical pharmacology reviewers / Drug interactions : perspectives of the Canadian Drugs Directorate / Overview of experimental approaches for study of drug metabolism and drug-drug interactions
Özet:
Drug-Drug Interactions is a comprehensive review of the scientific and regulatory perspectives of drug-drug interactions from the point-of-view of academia, industry, and government regulatory agencies. This book is intended for professionals in the pharmaceutical industry, health care, and governmental regulatory agencies. Topics of interest include the mechanistic understanding of drug-drug interactions, the prediction of drug-drug interaction potential of new drugs, and the avoidance of clinically significant drug-drug interaction in patients. Key Features * Provides useful references on the science of drug-drug interactions * Describes in a basic and comprehensive manner drug-drug interactions from the mechanistic viewpoint * Contains original data from academic and industrial laboratories * Presents an overview of regulatory agency positions.
Tür:
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Elektronik Erişim:
ScienceDirect http://www.sciencedirect.com/science/book/9780120329441 ScienceDirect http://www.sciencedirect.com/science/bookseries/10543589/43Mevcut:*
Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
RM302 .D78 1997 EB | 1180199-1001 | Elsevier E-Kitap Koleksiyonu | Arıyor... |
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