Front Cover; The Biochemistry of the Nucleic Acids; Copyright Page; Dedication; Table of Contents; Plates; Author's Preface; Abbreviations and Nomenclature; Chapter 1. Introduction; REFERENCES; Chapter 2. The Biological Functions of Nucleic Acids; 2.1 General; 2.2 Bacterial transforming factors; 2.3 The nature of the 'transformation' reaction; 2.4 Transduction phenomena; 2.5 The DNA of the cell nucleus; 2.6 Changes during mitotic division; 2.7 The metabolic stability of DNA; 2.8 The genetic function of DNA; 2.10 Extrachromosomal Inheritance; REFERENCES

Chapter 3. The Occurrence of Nucleic Acids3.1 Cytochemistry; 3.2 The Bacterial Cell; 3.3 The separation of cytoplasmic components; 3.4 Properties of the subcellular fractions: the mitochondria; 3.5 Lysosomes and Peroxisomes; 3.6 Ribosomes; 3.7 Polysomes; 3.8 The cell sap; 3.9 Cytoplasmic DNA; 3.10 The cell nucleus; 3.11 The isolation of cell nuclei; 3.12 The chemical composition of the cell nucleus; 3.13 Protamines and histones; 3.14 The RNA of the cell nucleus; 3.15 The nucleolus; 3.16 The chromosomes; 3.17 Histochemistry; 3.18 The Feulgen nucleal reaction; 3.19 Ultraviolet microscopy

3.20 Staining with basic dyes3.21 The ribonuclease and deoxyribonuclease tests; 3.22 Ultraviolet cytophotometry; REFERENCES; Chapter 4. Chemical Constituents of Nucleic Acids; 4.1 General; 4.2 Pyrimidine bases; 4.3 Purine bases; 4.4 Pentose sugars; 4.5 Deoxypentose sugars; 4.6 Nucleosides; 4.7 Nucleotides; 4.8 Coenzyme nucleotides; 4.9 Methods of preparation; REFERENCES; Chapter 5. Isolation and Characterization of Nucleic Acids; 5.1 General procedures for nucleic acid isolation; 5.2 Isolation of RNA; 5.3 Types of RNA; 5.4 Separation of RNA species; 5.5 The isolation of DNA; 5.6 Types of DNA

5.7 Separation of DNA species5.8 Separation of RNA, DNA and RNA/DNA hybrids; 5.9 The chemical determination of Nucleic Acids in tissues; 5.10 Ultraviolet absorption; 5.11 Determination of nucleic acid base composition; 5.12 Separation and estimation of bases, nucleosides and nucleotides; 5.13 Separation of oligonucleotides; REFERENCES; Chapter 6. The Structure of RNA; 6.1 The molar proportions of bases; 6.2 The primary structure of RNA; 6.3 Alkaline degradation; 6.4 Shorthand notation; 6.5 End groups; 6.6 The determination of nucleotide sequences; 6.7 The secondary structure of RNA

6.8 The Chemical Synthesis of PolyribonucleotidesREFERENCES; Chapter 7. The Structure of DNA; 7.1 The chemical composition of DNA; 7.2 Molecular Weight of DNA; 7.3 The Molar Proportions of Bases; 7.4 The Primary Structure of DNA; 7.5 The secondary structure of DNA; 7.6 Accepted abbreviations and short-hand notations for DNA; 7.7 The dynamic secondary structure of DNA; 7.8 The tertiary structure of DNA; 7.9 Double-stranded linear DNA; 7.10 Double-stranded cyclic DNA; 7.11 Single-stranded DNA; 7.12 Nucleotide sequence analysis of DNA; 7.13 Repetitive and satellite DNA