Conjugation-dependent carcinogenicity and toxicity of foreign compounds

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Başlık:

Conjugation-dependent carcinogenicity and toxicity of foreign compounds

Yazar:

Anders, M. W. (Marion Walter), 1936-

ISBN:

9780080581187

9780120329274

9781281712257

Yayın Bilgileri:

Fiziksel Tanımlama:

1 online resource (xvi, 519 pages) : illustrations

Seri:

Advances in pharmacology ; v. 27

Advances in pharmacology ; v. 27.

İçerik:

Front Cover; Conjugation-Dependent Carcinogenicity and Toxicity of Foreign Compounds; Copyright Page; Contents; Contributors; Chapter 1. Historical Perspectives on Conjugation-Dependent Bioactivation of Foreign Compounds; I. Metabolic Research Leading to Conjugation-Dependent Bioactivation of 4-Dimethylaminoazobenzene and 2-Acetylaminofluorene; II. Important Observations Leading to Bioactivation of Foreign Compounds via Glutathione Conjugation, Methylation, and Epoxide Formation and Hydrolysis; References; Part I: Glutathione-Dependent Toxicity.

Chapter 1. Enzymology of Microsomal Glutathione S-TransferaseI. Introduction; II. Catalysis; III. Activation; IV. The Activated Enzyme; V. Thiol Substrates; VI. Concluding Remarks; References; Chapter 2. Enzymology of Cytosolic Glutathione S-Transferases; I. Introduction; II. The GST Supergene Family; III. Structure of GSTs Including Their Active Sites; IV. Enzyme Kinetics; V. Gene Structure and Gene Regulation; VI. Specific Examples Illustrating the Properties of GSTs; VII. Conclusions; References; Chapter 3. Enzymology of Cysteine S-Conjugate ß-Lyases; I. Introduction.

II. Enzymes That Cleave the Thioether Bond of S-Substituted CysteinesIII. Bacterial Cysteine S-Conjugate ß-Lyases; IV. Mammalian Cysteine S-Conjugate ß-Lyases; V. Design of Prodrugs Directed toward Glutamine K/Cysteine S-Conjugate ß-Lyase in the Kidney; Vl. Conclusions; Note Added in Proof; References; Chapter 4. Formation and Fate of Nephrotoxic and Cytotoxic Glutathione S-Conjugates: Cysteine Conjugate ß-Lyase Pathway; I. Introduction; II. Biosynthesis of Toxic Glutathione S-Conjugates; III. Fate of S-Conjugates; IV. Bioactivation of Cytotoxic and Nephrotoxic Cysteine S-Conjugates.

V. Cellular Effects of Cytotoxic and Nephrotoxic Cysteine S-ConjugatesReferences; Chapter 5. Reversibility in Glutathione-Conjugate Formation; I. Introduction; II. Classes of Compounds That Undergo Reversible Conjugation; III. Conclusions; References; Chapter 6. Glutathione Conjugation as a Mechanism for the Transport of Reactive Metabolites; I. Introduction; II. Glutathione Conjugation as a Mechanism for the Transport of Redox Active Compounds; III. Transport of Glutathione-Conjugated Redox Compounds to the Kidney as a Common Factor in Chemical-Induced Nephrocarcinogenicity.

IV.?-Glutamyltranspeptidase and the Toxicity of Glutathione-Conjugated Redox CompoundsV. Targeting of Glutathione Conjugates to Neoplastic Tissues Expressing g-Glutamyltranspeptidase; VI. Developmental Toxicity o f Glutathione-Conjugated Redox Compounds; VII. Transport of Reversible Glutathione Conjugates; VIII. Glutathione, Nitric Oxide, and Endothelial-Derived Relaxing Compounds; IX. Summary; References; Chapter 7. Metabolism and Genotoxicity of Dihaloalkanes; I. Introduction; II. Adducts Derived from 1,2-Dihaloethanes; III. Other Dihaloalkanes.

Özet:

Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental. Conjugation reactions have long been associated with the detoxification of xenobiotics. Recent studies suggest that Phase II reactions are an important mechanism for the bioactivation of xenobiotics. This special volume of Advances in Pharmacology features a two-color dust jacket. Key Features * Summarizes the most recent information on: * Xenobiotic conjugation * Drug toxicity, hypersensitivity, and targeting Chemical carcinogenesis * Glutathione-, sulfate conjugate-, and glucuranide conjugate-dependent toxicity * Bioactivation and bioconversion.

Konu Başlığı:

Drugs -- Metabolism.

Pharmaceutical Preparations -- metabolism. (DNLM)D004364Q000378

MEDICAL -- Drug Guides.

MEDICAL -- Pharmacology.

MEDICAL -- Pharmacy.

MEDICAL -- Nursing -- Pharmacology.

Drugs -- Metabolism. (OCoLC)fst00898845

Toxiciteit.

Carcinogeniteit.

Geconjugeerde systemen.

Préparations pharmaceutiques -- Métabolisme.