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Reactive Polymeric Thin Films: I. Fabrication and Characterization of Degradable Amine-Reactive Films using Azlactone-Containing Polymers II. Encapsulation of Thermotropic Liquid Crystal Droplets 'Caged' in Hollow Polymer Capsules
Başlık:
Reactive Polymeric Thin Films: I. Fabrication and Characterization of Degradable Amine-Reactive Films using Azlactone-Containing Polymers II. Encapsulation of Thermotropic Liquid Crystal Droplets 'Caged' in Hollow Polymer Capsules
Yazar:
Zayas-Gonzalez, Yashira M., author.
ISBN:
9780438029248
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (250 pages)
Genel Not:
Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Advisors: David M. Lynn Committee members: Nicholas L. Abbott; Helen E. Blackwell; Regina M. Murphy; Sean P. Palececk.
Özet:
The work described in this thesis focuses on the development of approaches to the fabrication of polymer-based thin films and membranes using amine-reactive, azlactone-functionalized polymers. The first part of this thesis describes the layer-by-layer fabrication of thin films that can degrade or disassemble in aqueous environments in response to various stimuli. Two primary approaches to the reactive layer-by-layer assembly of amine reactive multilayer films were investigated using poly(2-vinyl-4,4-dimethylazlactone) (PVDMA) as a model amine-reactive building block. In a first approach, PVDMA was used in combination with degradable polyamine building blocks to fabricate coatings that are hydrolytically or enzymatically degradable. In a second approach, PVDMA was used in combination with disulfide-containing small-molecule diamine linkers to design films that degrade in reducing environments. These approaches lead to films that retain reactive azlactone functionality that permit further functionalization, after fabrication, by treatment with other amine-based nucleophiles. These strategies provide new opportunities to design coatings, interfaces, capsules, and other materials for biotechnological or biomedical applications in which degradability or environmental transience are useful. The second part of this thesis describes fundamental studies investigating the encapsulation of thermotropic liquid crystals (LCs) into micrometer-sized hollow capsules fabricated by the layer-by-layer assembly of PVDMA and branched poly(ethylenimine). These studies include characterization of (i) capsule filling, (ii) the behaviors of LC droplets 'caged' in these capsules, and (iii) changes in the optical appearances of caged LC droplets upon exposure to aqueous amphiphiles. A substantial focus of this work focuses on characterizing the behaviors of these caged LCs in biological media and in contact with living mammalian cells. It is demonstrated that caged LCs can be immobilized on and, in some cases, internalized by mammalian cells without affecting a response in the LC, permitting the use of these droplets as chemical sensors. This approach provides new means for the real-time detection of agents in extracellular environments and new opportunities to characterize the behaviors of thermotropic LCs in intracellular environments.
Notlar:
School code: 0262
Konu Başlığı:
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(677886.1) | 677886-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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