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![Role of Breastfeeding Duration, Maternal Smoking during Pregnancy, and DNA-Methylation for the Risk of Eczema için kapak resmi Role of Breastfeeding Duration, Maternal Smoking during Pregnancy, and DNA-Methylation for the Risk of Eczema için kapak resmi](/client/assets/d79c3e4af2b6d196/ctx/images/no_image.png)
Role of Breastfeeding Duration, Maternal Smoking during Pregnancy, and DNA-Methylation for the Risk of Eczema
Başlık:
Role of Breastfeeding Duration, Maternal Smoking during Pregnancy, and DNA-Methylation for the Risk of Eczema
Yazar:
Mukherjee, Nandini, author.
ISBN:
9780355983746
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (136 pages)
Genel Not:
Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Advisors: Wilfried Karmaus Committee members: Syed Hasan Arshad; John Holloway; Thomas R. Sutter; Hongmei Zhang.
Özet:
Prior studies linking breastfeeding duration and maternal gestational smoking, respectively, to offspring eczema report contradictory findings. However, it is not known whether maternal gestational smoking and breastfeeding duration can jointly influence eczema and whether these exposures mediate their effect on eczema via DNA Methylation (DNA-M) of CpG (cytosine-phosphate-guanine) sites.
With data from the Isle of Wight (IOW) birth cohort, UK, we first evaluated the combined effect of maternal gestational smoking and breastfeeding duration on eczema at ages 1-to-2 (n=980), 4 (n=902), 10 (n=966), and 18 years (n=929) using Generalized estimating equations (GEE). We found a protective effect of longer duration of breastfeeding (weeks) on eczema if the mother smoked during gestation (objective (i)). The risk ratios (95% CI) for eczema related to maternal gestational smoking for 3, 9, 15, 21 weeks of breastfeeding were 0.88 (0.66, 1.20), 0.74 (0.54, 1.01), 0.62 (0.41, 0.93), and 0.51 (0.3, 0.88), respectively.
Next, we investigated whether DNA-M at age 10 can mediate the effect of breastfeeding duration on eczema at age 18 (n=276) using linear, log linear regression and structural equation modelling. The CpGs cg03605610 (between NRC2 and LINC01276), cg04928096 (AXIN1), cg26375057 (ZIC1) and cg26979504 (HHEX) were in the causal pathway between duration of breastfeeding and eczema mediating its protective effect (indirect effect estimate: -0.008, p-value: 0.022 (cg03605610); Estimate: -0.008, p-value: 0.049 (cg04928096); Estimate: -0.008, p-value: 0.034 (cg26375057); Estimate: -0.007, p-value: 0.021 (cg26979504)).
Finally, we evaluated whether DNA-M at age 10 associated with combined effect of gestational smoking and duration of breastfeeding can explain the risk of eczema using linear and log linear regression. We found cg07208825 (ALMS1P), cg12954512 (Intergenic) and cg21601919 (FGF18) to be associated with duration of breastfeeding if the mother smoked during gestation (Estimate: -0.006, p-value: 0.046 (cg07208825); Estimate: 0.021, p-value: 0.036 (cg12954512); estimate: 0.008, p-value: 0.016 (cg21601919). These CpGs were also associated with eczema at age 18 (Risk-ratio: 14.23, p-value: 1.27E-07 (cg07208825); Risk-ratio: 0.62, p-value: 3.90E-03 (cg12954512); Risk-ratio: 0.18, p-value: 1.56E-06 (cg21601919).
Future studies are required to corroborate these findings, and understand how the breastmilk composition if the mother smoked during pregnancy influences these genes affecting eczema pathogenesis.
Notlar:
School code: 1194
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(678748.1) | 678748-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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