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New polyurethane nail lacquers for the delivery of antifungal drugs
Başlık:
New polyurethane nail lacquers for the delivery of antifungal drugs
Yazar:
Valdés, Bárbara Susana Gregorí, author.
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (242 pages)
Genel Not:
Source: Dissertation Abstracts International, Volume: 76-07C.
Özet:
Nail fungal infections frequently addressed as onychomycosis present a considerable prevalence on the global population. Despite not being a life-threatening disease, this infection causes several social problems to the infected patients. Unfortunately, the topical therapy available, does not include one of the most effectively drugs and oral therapy comprises several problems. Nail lacquers are solutions of film forming polymers, which leave a film on the nail plate after solvent evaporation. This polymer film can be water resistant or water soluble and can act as a drug reservoir, allowing a drug to permeate through the nail plate. The nail lacquers water resistant are occlusive and adhesive to the nail. They present advantages regarding nail hydration, permanence on the nail plate and patient compliance, when compared to creams, gels and solutions. The development of polyurethane based nail lacquers for the delivery drugs to treat onychomycosis is still a challenge. Nowadays there are drugs with pharmacological activity (antifungal) for treatment of onychomycosis (i.e. terbinafine hydrochloride), but there is no nail lacquer formulation in the market capable of delivering them into the nail with success. Polyurethanes are being used for sustained and controlled delivery of various drugs. The development of a new polyurethane based on carbohydrates for the delivery of antifungal (terbinafine hydrochloride and ciclopirox olamine) to treat onychomycosis, is the main aim of this thesis. The thesis is divided in two main topics: The first part presents the synthesis of polyurethanes from carbohydrates and derivatives. The biocompatible polyurethanes were successfully synthesized employing carbohydrates and aliphatic isocyanates. The polyurethanes were synthesized by pre polymerization method. This process allows maintain better control the structure and properties of the final polymer, through a simple change of chain extender. It was possible to obtain polyurethanes with different properties from the same pre-polymer, that are typically liquids, which facilitates handling on an industrial scale, when compared with monomeric isocyanate systems. The polyurethanes were characterized by FTIR, NMR, GPC and MALDI-TOF. The biocompatibility of these materials was also assessed using keratinocytes cell. In the second part of our work, four polymers were used to prepare nail lacquers containing terbinafine hydrochloride as a model drug. The results obtained from the structural/characterization analysis of these PU based nail lacquers, comprising all the data and information that allowed the selection of the best of them to optimize the final formulations. At this stage, only one of the tested PU was selected to the complete physical, chemical and microbiological studies with two drug models: terbinafine hydrochloride and ciclopirox olamine. PU based nail lacquers with different amounts of the polyurethane selected previous were prepared. Cytotoxicity, wettability, SEM, adhesion test, viscosity, in vitro release and permeation studies as well as the antifungal activity were performed.
Notlar:
School code: 7024
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(678868.1) | 678868-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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