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Aggregation Inhibition and Detection of Alzheimer's Amyloidogenic and Oligomeric Peptides
Başlık:
Aggregation Inhibition and Detection of Alzheimer's Amyloidogenic and Oligomeric Peptides
Yazar:
Elbassal, Esmail A. E., author.
ISBN:
9780438012615
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (160 pages)
Genel Not:
Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Advisors: Deguo Du Committee members: Mare Cudic; Andrew C. Terentis; Ewa P. Wojcikiewicz.
Özet:
Protein aggregation, oligomer and fibril formation is one of the dominant characteristics in the pathogenesis of a number of neurodegenerative diseases, such as Alzheimer's disease (AD). Inhibition of toxic oligomer and fibril formation is one of the approaches to find potential drug candidates for AD. Additionally, early diagnosis of these amyloid species can provide mechanistic understanding of protein aggregation and thus can pave the way for preventing the onset of AD. The aim of this dissertation was 1) to explore the effects of charged cholesterol derivatives on the aggregation kinetic behavior of Amyloid-beta40 (Abeta40), 2) to probe Abeta40 oligomer and amyloid formation in vitro using gold nanoparticles (AuNPs), and 3) to monitor the kinetic effect of various natural product molecules on Abeta40 aggregation in vitro. In the first chapter, a general introduction about AD as an amyloidogenic disease, amyloid cascade hypothesis, and the manipulation of Abeta peptides aggregation kinetics using different approaches was presented. In the second chapter, we studied the effects of oppositely charged cholesterol derivatives on the aggregation kinetics of Abeta. In the third chapter, we developed a gold nanoparticles (AuNPs) assay to probe Abeta40 oligomers and amyloid formation. In chapter IV, we monitored the effects of various small molecules on the aggregation kinetics of Abeta40. In chapter V, we discussed the methods and experimental details.
Notlar:
School code: 0119
Tüzel Kişi Ek Girişi:
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(680285.1) | 680285-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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