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![Fast Isotope Ratio Mass Spectrometry (FIRMS): A Tandem Mass Spectrometry Technique for the Rapid and Semi-comprehensive Evaluation of Isotope Ratios için kapak resmi Fast Isotope Ratio Mass Spectrometry (FIRMS): A Tandem Mass Spectrometry Technique for the Rapid and Semi-comprehensive Evaluation of Isotope Ratios için kapak resmi](/client/assets/d79c3e4af2b6d196/ctx/images/no_image.png)
Fast Isotope Ratio Mass Spectrometry (FIRMS): A Tandem Mass Spectrometry Technique for the Rapid and Semi-comprehensive Evaluation of Isotope Ratios
Başlık:
Fast Isotope Ratio Mass Spectrometry (FIRMS): A Tandem Mass Spectrometry Technique for the Rapid and Semi-comprehensive Evaluation of Isotope Ratios
Yazar:
Ochieng, Fredrick, author.
ISBN:
9780355975444
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (144 pages)
Genel Not:
Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Advisors: Brian A. Logue Committee members: Bruce Bleakley; Matthew Miller; Douglas Raynie.
Özet:
Isotope ratios (IRs) are a measure of the variation in abundance of light isotopes versus heavy isotopes of an element, e.g. 1H/ 2H, 12C/13C, and 14N/ 15N. Because IRs change as a molecule undergoes certain chemical and physical processes, they represent unique fingerprints that can be used to trace the source of a chemical compound. Current techniques for determination of IRs each have major limitations, such as loss of structural information, vulnerability to contamination, high cost, large sample size requirements, low precision, limited applicability, and lengthy analysis. Fast Isotope Ratio Mass Spectrometry (FIRMS) was developed as a next-generation analytical technique for robust measurement of IRs using tandem mass spectrometric data. Based on the FIRMS nonlinear mathematical model, the difference between predicted and experimental tandem mass spectrometric data was minimized by modifying isotopic fractional abundances of the atoms involved. FIRMS was used to calculate the isotope abundances of molecules of 17 compounds. FIRMS produced excellent precision, with IRs standard deviations of less than 1‰, for delta 13C compared with IRMS in a fraction of the time. FIRMS also produced excellent accuracy for delta13C values with an absolute error of less than 1.6‰ compared to IRMS. It was also successfully coupled with LCMSMS to analyze delta13C for DIMPA, caffeine and acetylsalicylic acid with standard deviation of less than 1‰ and accuracies within 1‰ compared to IRMS. The bivariate plot of FIRMS versus IRMS showed an excellent R2 of 0.992 with a slope of 1, validating the new technique as an accurate isotope ratio measurement technique. FIRMS offers several advantages over other methods of IR determination, and may ultimately become the preferred method for determination of IRs. The disciplines that will benefit from development of FIRMS include: 1) forensic science, 2) environmental chemistry, 3) geology, 4) geochemistry, 5) cosmochemistry, 6) food sciences, 7) earth science, and 8) pharmaceutical science. FIRMS will make IR analysis more widely available, fast and less expensive for scientists to conduct research in these fields, as well as train new graduate students for future scientific research and development in this area.
Notlar:
School code: 0205
Tüzel Kişi Ek Girişi:
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(680616.1) | 680616-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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