Eylem Seç
Engineered nanomaterials in food: Assessing their behavior and impact in the gastrointestinal tract
Başlık:
Engineered nanomaterials in food: Assessing their behavior and impact in the gastrointestinal tract
Yazar:
Sohal, Ikjot Singh, author.
ISBN:
9780438006638
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (197 pages)
Genel Not:
Source: Dissertation Abstracts International, Volume: 79-10(E), Section: B.
Advisors: Dhimiter Bello.
Özet:
Engineered nanomaterials are being increasingly used as additives in food, especially the food products consumed by children such as candies, chewing gums and donuts. The safety and toxicity data on these ingested engineered nanomaterials (iENM) is variegated and marked by limited agreement between similar studies. This work aimed at a comprehensive review of the iENM toxicity literature in the past decade (2007 - 2017) with the with the objectives of identifying best practices and recommending more relevant in vitro models of iENM toxicity assessment. Only 21% of the studies used food-grade nanomaterials for testing; dissolution kinetics of test nanomaterials was evaluated in only 12% of the studies and moreover, only 1 study attempted to prepare and characterize standardized nanoparticle dispersions. The dissolution behavior and biodurability of 4 most prominent iENM (Ti02, SiO 2, ZnO and two iron oxides) in the gastrointestinal (GI) environment, which to the best of our knowledge has not been studied yet, were further evaluated in simulated digestive fluids and the iENM were ranked based on their biodurability and persistence in GI environment. TiO2 was found to be the most biodurable and persistent iENM in the simulated GI fluids, followed by iron oxides, of which the rod-like morphology was more biodurable and persistent than the acicular one. SiO2 and ZnO were less biodurable than Fe2O3, with 65.5% and 100% dissolution in the gastric phase, respectively. Finally, a comparative study on the toxicity of the above-mentioned iENM was performed in two culture systems which addressed the methodological aspects discussed in the review. The triculture system was found to be a much efficient epithelial barrier due to its mucus-secreting properties, and more sensitive at cellular level and cytokine response in comparison to the monoculture system, consistent with recent in vivo findings. We conclude with a set of recommendations to guide future iENM toxicity studies and to develop/adopt more relevant in vitro model systems representative of in vivo animal and human iENM exposure scenarios.
Notlar:
School code: 0111
Tüzel Kişi Ek Girişi:
Mevcut:*
Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(684001.1) | 684001-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
On Order
Liste seç
Bunu varsayılan liste yap.
Öğeler başarıyla eklendi
Öğeler eklenirken hata oldu. Lütfen tekrar deneyiniz.
:
Select An Item
Data usage warning: You will receive one text message for each title you selected.
Standard text messaging rates apply.