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The effect of a raised environmental temperature on the metabolic response to thermal injury in the rat
Başlık:
The effect of a raised environmental temperature on the metabolic response to thermal injury in the rat
Yazar:
Drury, John Kenneth, author.
ISBN:
9780438057494
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (251 pages)
Genel Not:
Source: Dissertation Abstracts International, Volume: 76-08C.
Advisors: I. A. Boyd.
Özet:
Whole body energy balance and associated biochemical changes after a standard thermal injury, were studied in rats, housed in a purpose built animal and laboratory unit, utilising a unique small animal calorimetry system. Experiments were conducted at 20°C and 30°C, the effect of environmental temperature being noted. in order to monitor loss of lean muscle mass, 65Zinc isotope studies were performed after an initial investigation of the normal distribution and metabolism of 65Zinc in the rat which showed the major concentrating organs to be muscle and bone. A 20% body surface area burn failed to produce a significant metabolic response when the rat was allowed free access to food and water. Before a 25% body surface area burn at 20°C, the rat was in positive nitrogen balance gaining 5.6 g weight per g nitrogen retained. The energy required for this growth was 7.5 Kcal per g of weight gain. Therefore, failure to grow as well as actual weight loss must be considered in assessing results of injury. After injury at 20°C, tissue reserves were mobilised to minimise an energy deficit consequent on a 300% increase in evaporative water loss. Three distinct weight loss phases were identified as being related to loss of fat stores initially and later protein reserves as deduced from calorific values of catabollsed tissue and partial carcass analysis. Despite weight loss, the rat continued to retain nitrogen after injury, questioning its role as an analogue for adult humans In metabolic studies. The metabolic response was reflected by increased excretion rates of urinary nitrogen, creatine and 65Zinc. At 30°C, sensible and insensible heat losses were reduced by 45% and 35%. Despite a 34% decrease in food intake, there was less of an energy deficit resulting in no increase in excretion rates of urinary nitrogen, creatine and 65Zinc. A less negative energy balance had the effect of mobilising less fat stores and sparing catabolism of structural protein. The effect of the raised environmental temperature appeared to be one of diminishing the protein contribution to energy balance after injury rather than a physiological adaptation to heat. The possible mechanism of the effect when related to hormonal changes after injury is suggested with reference to systems analysis.
Notlar:
School code: 0547
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(684608.1) | 684608-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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