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Characterisation of protein kinase C in chick embryo tissues and hepatocytes: Role in insulin sigalling
Başlık:
Characterisation of protein kinase C in chick embryo tissues and hepatocytes: Role in insulin sigalling
Yazar:
Belbrahem, Atika, author.
ISBN:
9780438083370
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (298 pages)
Genel Not:
Source: Dissertation Abstracts International, Volume: 76-08C.
Özet:
Two main forms of protein kinase C (PKC) activity were found in chick embryo liver using DE52-cellulose chromatography: peak I and peak II. Peak I exhibits enzymatic behaviour essentially identical to that of rat and chick brain. However, immunological and enzymological characteristics of peak II clearly distinguish it from the other conventional and novel PKCs thus far identified. Epidermal growth factor (EGF) mimicked the effect of insulin to increase leucine incorporation into protein in cultures of chick embryo hepatocytes. The lack of additive effect of insulin and EGF on leucine incorporation suggests that the two hormones might share common intracellular signalling routes for modulation of protein synthesis. In contrast phorbol esters failed to mimic the effects of the above growth hormones. Pretreatment of hepatocytes with H7, a potent inhibitor of PKC or PKC depletion did not alter insulin or EGF stimulation of leucine incorporation. Employing two different assay systems of PKC (immunological and phosphorylation assay) phorbol ester and insulin/or EGF effects on the activity and intracellular distribution of PKC in chick embryo hepatocytes were compared. Phorbol ester treatment resulted in translocation of PKC from cytosolic to particulate compartments of cells. No such translocation of cytosolic PKC activity was observed in response to treatment with either EGF or insulin. These results, suggest that changes in PKC activity or intracellular distribution are not a necessary concomitant of the signalling cascades activated by insulin or EGF.
Notlar:
School code: 1543
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(686874.1) | 686874-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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