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The Nervous System and Cancers of the Head and Neck
Başlık:
The Nervous System and Cancers of the Head and Neck
Yazar:
Graves, Christian A., author.
ISBN:
9780438111455
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (93 pages)
Genel Not:
Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B.
Advisors: Lucia A. Pirisi-Creek Committee members: Peter Botrous; Kim Creek; James Wells; Susan Wood.
Özet:
The anatomy of the head and neck is closely associated with the nervous system which plays an important role in the prognosis of head and neck cancer (HNC). However, the molecular interactions between these compartments and HNC remain poorly understood. We present a novel big data approach utilizing clinical data, sequencing, and machine learning to identify and validate potential molecular pathways by which the nervous system affects the development and progression of HNC. Our studies demonstrate across multiple datasets that perineural invasion (PNI) frequently occurs in HPV+ HNC. Furthermore, we show novel activating and missense mutations and pathways that may play important roles in the progression of HNC. We hypothesized that HPV+ cancers might be driven by different neurotrophic-associated genes and programs. We observed that neuroendocrine and neurotrophin signaling through the nerve growth factor receptor (NGFR) can be observed in differentiating HPV+ versus HPV- and PNI+ versus PNI- HNC. These observations may provide significant therapeutic targets for HNC.
Notlar:
School code: 0202
Konu Başlığı:
Tüzel Kişi Ek Girişi:
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(688098.1) | 688098-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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