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Anthocyanin and Phenolic Derivatives in Blueberry Juice Produce CYP3A Inhibition in vitro, and Identification of These Compounds and Related Derivatives in Human Plasma
Başlık:
Anthocyanin and Phenolic Derivatives in Blueberry Juice Produce CYP3A Inhibition in vitro, and Identification of These Compounds and Related Derivatives in Human Plasma
Yazar:
Yu, Xiao, author.
ISBN:
9780438031159
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (41 pages)
Genel Not:
Source: Masters Abstracts International, Volume: 57-06M(E).
Advisors: David Greenblatt.
Özet:
Interactions of natural products with prescription drugs have become an issue of medical and public health concern. Blueberry juice at low concentrations produces inhibition of cytochrome P450 (CYP) 3A activity in vitro . As the pharmacologically active constituents in blueberry juice, anthocyanin and phenolic reveal inhibit effect on CYP3A. Of 4 anthocyanin derivatives and 3 phenolic compounds were measured as potential inhibitor in screen inhibition test, result showed that Malvidin-3-glucoside, Peonidin-3-glucoside, Delphinidin-3-glucoside, Cyanidin-3-glucoside and Quercetin inhibited examined human microsome in a concentration-dependent manner featuring IC50 values from 8.8uM up to 89.2uM. To better understand the absorption and pharmacokinetic profile of blueberry anthocyanin and phenolic after consumed by human, a clinical study was involved. In human study, 12 healthy volunteers were required to take either water (300ml) or 50:50 mixture of lowbush and highbush blueberry juice (300ml) twice a day, and the blood samples were drawing during 12h after index substrate administration. Here, proteins remove, liquid-liquid extraction, high-performance liquid chromatography and mass spectrometry techniques are described for isolation, separation and identification of anthocyanin and phenolic in human plasma.
Notlar:
School code: 0845
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
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