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![Proteasome and VCP Inhibition Blocks Necroptosis in HT-29 Cells için kapak resmi Proteasome and VCP Inhibition Blocks Necroptosis in HT-29 Cells için kapak resmi](/client/assets/d79c3e4af2b6d196/ctx/images/no_image.png)
Proteasome and VCP Inhibition Blocks Necroptosis in HT-29 Cells
Başlık:
Proteasome and VCP Inhibition Blocks Necroptosis in HT-29 Cells
Yazar:
Gurol, Kerem Cahit, author.
ISBN:
9780438031319
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (27 pages)
Genel Not:
Source: Masters Abstracts International, Volume: 57-06M(E).
Advisors: Alexei Degterev.
Özet:
Necroptosis is a programmed form of cell death mediated by the formation of a detergent-insoluble protein complex called necrosome. Receptor Interacting Protein Kinases (RIPK) 1 and 3 have been identified as the key components of the necrosome. Phosphorylation and ubiquitination of several RIPK1/3 residues have been implicated to play important roles in regulating apoptosis and necroptosis.
As the main mechanism for cellular protein degradation, ubiquitin-proteasome system (UPS) has been associated with a myriad of cellular pathways, including apoptosis. However, the mechanism and function of UPS under apoptotic or necroptotic conditions are poorly understood.
Here we report that proteasome inhibitor bortezomib and Valosin-Containing Protein (VCP) inhibitor NMS-873 inhibit necroptosis in human colorectal cancer HT-29 cells. VCP inhibition clearly changes the ubiquitination profile of RIPK1 and RIPK3 in the necrosome. RIPK1 interacts with VCP upon TNFalpha stimulation in a complex separate from the necrosome or TNF Receptor 1 signaling complex.
Notlar:
School code: 0845
Konu Başlığı:
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(689632.1) | 689632-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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