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Analysis of alpha-(N)-Heterocyclic Thiosemicarbazone Derivatives Inhibition on Human Topoisomerase IIalpha and on the Reduction of Cell Viability in a Breast Cancer Cell Line
Başlık:
Analysis of alpha-(N)-Heterocyclic Thiosemicarbazone Derivatives Inhibition on Human Topoisomerase IIalpha and on the Reduction of Cell Viability in a Breast Cancer Cell Line
Yazar:
Bowman, Sarah B., author.
ISBN:
9780355940701
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (147 pages)
Genel Not:
Source: Masters Abstracts International, Volume: 57-06M(E).
Advisors: Xiaohua Jiang Committee members: Edward Lisic; Xuanzhi Zhan.
Özet:
DNA is a biological molecule that contains the genetic material involved in the growth, development, functioning, and reproduction of almost all living organisms. DNA is highly condensed in the nucleus of the cell. Human Topoisomerase II (Topo II) is essential to unravel topological complications of DNA, including catenation, knotting, and supercoiling. The alpha isoform of Topo II is required for cell survival and proliferation. It is commonly targeted by chemotherapeutics since cancer cells are under rapid proliferation. Recent studies have shown that thiosemicarbazones (TSC) inhibit Topo IIalpha significantly in cancer cells. To determine the structure-activity relationship of TSCs and their effect on Topo IIalpha and cancer cells, several series of TSCs will be examined in Topo IIalpha-mediated DNA relaxation assay and their cytotoxicity is tested on breast cancer cells.
Notlar:
School code: 0390
Tüzel Kişi Ek Girişi:
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(690645.1) | 690645-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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