Orally-Dosed Citalopram Stimulates Small Intestinal Mucosal Growth
Başlık:
Orally-Dosed Citalopram Stimulates Small Intestinal Mucosal Growth
Yazar:
Zhang, Lucy, author.
ISBN:
9780438132931
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (39 pages)
Genel Not:
Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B.
Advisors: Robert A. Cowles Committee members: John Geibel.
Özet:
Parenterally-administered selective serotonin reuptake inhibitors (SSRI), such as citalopram, increase intestinal mucosal absorptive surface by day 7 of treatment. We hypothesized that enteral citalopram would also induce intestinal mucosal growth, thus allowing for therapy with an oral agent. In the study's first phase, C57BL/6 mice received peanut butter (PB) pellets containing 10, 50, or 100 mg/kg/day citalopram for 7 days; or 25 mg/kg/day citalopram for 14 or 21 days; or plain PB pellets for 7, 14, or 21 days. In the second phase, C57BL/6 mice received 0, 10, 25, or 50 mg/kg/day citalopram in drinking water for 2, 3, 6, or 8 weeks, or for 6 weeks followed by 2 weeks of drug withdrawal. Two-centimeter ileal segments were harvested and prepared for microscopic assessment of villus height (VH), crypt depth (CD), villus width (VW), and crypt width (CW). Mucosal surface area (MSA) was calculated and data were compared using Student's t-test. Enteral citalopram given for 14 days in PB pellets resulted in an increased VH (p <0.0001), VW (p = 0.0058), and ileal MSA per mm2 (p = 0.0007). The increase in MSA was sustained at 21 days (p <0.0001). When citalopram was given in drinking water, VH was greater than controls by week 3 (p <0.0001 across all three doses); however, MSA per square millimeter was not significantly increased, regardless of treatment dose or duration. Further work is needed, but SSRIs show some promise in the short-term period as oral therapy for serious intestinal disorders such as short bowel syndrome.
Notlar:
School code: 0265
Tüzel Kişi Ek Girişi:
Mevcut:*
Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(690653.1) | 690653-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
On Order
Liste seç
Bunu varsayılan liste yap.
Öğeler başarıyla eklendi
Öğeler eklenirken hata oldu. Lütfen tekrar deneyiniz.
:
Select An Item
Data usage warning: You will receive one text message for each title you selected.
Standard text messaging rates apply.