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A Comprehensive Analysis of Aromatic-Proton Mediated Hydrogen Bonds
Başlık:
A Comprehensive Analysis of Aromatic-Proton Mediated Hydrogen Bonds
Yazar:
Alshamrani, Mona S., author.
ISBN:
9780355974720
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (74 pages)
Genel Not:
Source: Masters Abstracts International, Volume: 57-06M(E).
Advisors: Suvobrata Chakravarty Committee members: Halaweish Fathi; Darrington Joseph; Gupta Tanya.
Özet:
Hydrogen bonds play critical role in folding, structure and recognition of biological macromolecules (e.g., proteins, RNA, DNA). In addition to classical hydrogen bonds (e.g., --OH---O=, --OH---O--, --NH---O-- etc.), structural analysis of protein and nucleic acids, almost a decade ago, showed that hydrogen bonds (e.g., CH---O) with hydrogen atoms on aliphatic carbon atoms (hereafter, aliphatic-protons) also play very important role in the structure and function of biomolecules. Even though, protons of aromatic ring systems (hereafter, aromatic-protons) are more polar than the aliphatic-protons, systematic analysis of hydrogen bonds of aromatic-protons have not been carried out. Therefore, I carried out a systematic analysis of hydrogen bonds that are made with aromatic-protons of tryptophan, tyrosine and phenylalanine amino acids in high-resolution structures of proteins and their complexes using a computer program that I created in R- and Perl languages. The analysis showed that aromatic CH---O are very common in proteins and tryptophan-CD1 is the most frequent participant in aromatic CH---O hydrogen bonds. The normalized frequency of occurrences of aromatic CH---O hydrogen bonds are greater than that of the aliphatic CH---O hydrogen bonds. Therefore, like aliphatic CH---O hydrogen bonds we anticipate that aromatic CH---O hydrogen bonds are likely to play equally, if not more, important role in macromolecular folding, stability and recognition. The numerous examples of aromatic CH---O hydrogen bonds observed here provides a good source of information that can be probed further by experiments to validate their important contribution.
Notlar:
School code: 0205
Tüzel Kişi Ek Girişi:
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(690693.1) | 690693-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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