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The role of wild leporids as reservoirs of infectious agents
Başlık:
The role of wild leporids as reservoirs of infectious agents
Yazar:
Carvalho, Carina Luísa da Costa, author.
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (503 pages)
Genel Not:
Source: Dissertation Abstracts International, Volume: 76-09C.
Özet:
The European wild rabbit (Oryctolagus cuniculus) and the Iberian hare (Lepus granatensis), are keystones species in various ecosystems of the Iberian Peninsula and on the local game-based economy.
This thesis aimed to investigate the rabbit haemorrhagic disease virus 2 (RHDV2), detected in Portugal in 2012 and currently disseminated in the continent and autonomous regions (Azores, Madeira, Berlengas). Given its alarming impact in the wild rabbit populations, the Portuguese Government has recently activated a plan aiming the control of the disease (Despatch 4757/2017 of May 31st).
A second objective of this thesis was the epidemiological surveillance of Francisella tularensis zoonotic vector-borne pathogenic bacterium, with potential impact on Human Health. The Iberian hare is considered reservoir and potential sentinel species for this pathogen.
Several methodologies were used to carry out the studies presented in this work, including basic pathology, microbiology and molecular methods. Data analysis involved the resource to phylogenetic inference, statistical programs and bioformatics (e.g. R software).
This work enabled the development and validation of the first molecular diagnostic method for RHDV2, currently figuring in the OIE manual, and allowed insights into to the virus dynamic evolution in different epidemiologic and geographic contexts, widening the comprehension of RHDV2 phylogenetic relations among the strains that circulate in Portugal from 2012 until 2017.
This study also made possible to ascertain the tularaemia epidemiologic situation in Portugal, confirming the role of wild leporids as reservoirs for the agent and enabling preliminary conclusions on Public Health risk in the country. Moreover, this work allowed confirming ticks as the main vectors for Francisella tularensis in Portugal.
Globally, this work contributed to the state-of-the-art of both infections and produced relevant information that can be used to adjust the medical and sanitary prophylactic measures of both diseases to the present reality.
Notlar:
School code: 7023
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(691204.1) | 691204-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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