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Host Heterogeneity and the Dynamics of Pathogen Diversity
Başlık:
Host Heterogeneity and the Dynamics of Pathogen Diversity
Yazar:
Ranjeva, Sylvia, author.
ISBN:
9780438087859
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (122 pages)
Genel Not:
Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B.
Advisors: Greg Dwyer; Sarah Cobey Committee members: Stefano Allesina; Mercedes Pascual.
Özet:
A central goal of ecology is to explain the diversity of coexisting species. Analogously, fundamental questions in epidemiology center around coexistence in pathogen communities. Classical models of strain competition predict variable coexistence dynamics depending upon the strength of cross-immunity. However, heterogeneity among human hosts, through variation in population structure and immune responses, can also profoundly affect coexistence. This dissertation investigates the intersection of immune-mediated competition and host heterogeneity to explain the dynamics of pathogen diversity in two viral communities: human papillomavirus (HPV) and influenza A viruses. We test hypotheses about viral dynamics by fitting mechanistic models to longitudinal data. We show that the prevalence and coexistence of over 200 genetically distinct HPV types are maintained by recurring infection within individuals of type-specific highrisk subpopulations. We then show that the dynamics of immune protection after influenza infection differ between children and adults, signaling substantial variability in the population-level selective pressures that shape the diversity of influenza strains.
Notlar:
School code: 0330
Mevcut:*
Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(691439.1) | 691439-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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