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![A Novel Screen for the Evaluation of Developmental Neurotoxicity of Effluent Pollutants Using the Xenopus Tadpole: An Assessment of Bisphenol-a & Caffeine için kapak resmi A Novel Screen for the Evaluation of Developmental Neurotoxicity of Effluent Pollutants Using the Xenopus Tadpole: An Assessment of Bisphenol-a & Caffeine için kapak resmi](/client/assets/d79c3e4af2b6d196/ctx/images/no_image.png)
A Novel Screen for the Evaluation of Developmental Neurotoxicity of Effluent Pollutants Using the Xenopus Tadpole: An Assessment of Bisphenol-a & Caffeine
Başlık:
A Novel Screen for the Evaluation of Developmental Neurotoxicity of Effluent Pollutants Using the Xenopus Tadpole: An Assessment of Bisphenol-a & Caffeine
Yazar:
Donnelly, Katelynne B., author.
ISBN:
9780438021174
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (55 pages)
Genel Not:
Source: Masters Abstracts International, Volume: 57-06M(E).
Advisors: Kara G. Pratt Committee members: David M. Bagley; Frank J. Rahel.
Özet:
The Laramie Wastewater Treatment Plant discharges its treated effluent into the Laramie River. Although this water is free of chemicals in concentrations that are lethal to organisms, small amounts are still present. These chemicals are a combination of pharmaceuticals, industrial wastes, personal care products, and pesticides. Currently, little is known about how these sub-lethal concentrations affect the growth and survival of organisms, especially during embryonic development of the central nervous system.
In this study, a novel screen was developed to easily identify neural circuit deficits in the visual system of the developing Xenopus laevis tadpole when exposed to sublethal concentrations of chemicals found in wastewater effluent. Screening consisted of an initial behavioral evaluation, followed by neuron imaging and electrophysiological recordings. When testing the effects of bisphenol-A (BPA) and caffeine, two chemicals commonly present in wastewater effluent, we found that tadpoles exposed to 15 microM BPA and/or 515 microM caffeine had deficits in visually guided behaviors, visual circuit function, and neuron morphology compared to control tadpoles.
Notlar:
School code: 0264
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(692802.1) | 692802-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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