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Characterization of Injectable Liquid Embolic Particles
Başlık:
Characterization of Injectable Liquid Embolic Particles
Yazar:
Cotter, Trevor Robert, author.
ISBN:
9780438008472
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (104 pages)
Genel Not:
Source: Masters Abstracts International, Volume: 57-06M(E).
Advisors: Timothy A. Becker Committee members: Robert S. Kellar; Christopher J. Mann.
Özet:
Cerebral aneurysms can be found in over 2% of the American population, and their rupture into hemorrhagic stroke carries a 40% mortality rate. This makes their treatment important to clinicians trying to prevent this from happening to millions of people. A novel polymer, poly(propylene glycol) diacrylate and pentaerythritol tetrakis (3-mercaptopropionate) (PPODA-QT), has been developed in order to successfully embolize these aneurysms. It is injected through a catheter into the aneurysm, where it cures and the aneurysm can heal itself, eliminating the risk of rupture and stroke. This thesis focuses on the embolic risks presented during the injection and curing of PPODA-QT.
The first aim of this project was to build an endovascular flow model that could accurately mimic conditions found in the human body. This was used to practice procedures and evaluate embolic risk. In the second aim, multiple microscopy methods were used to capture and analyze particles shed downstream during the procedure to ensure that the injection would be safe for use in living models. In the final aim, rabbit aneurysm models were used to confirm that no negative embolic effects were observed.
A model was built that could control pressure, temperature, and pressure. The model was designed with customizable inserts that could be changed to model various anatomies. Differential interference contrast (DIC) microscopy was used to analyze filters that captured downstream particles produced during the procedure. Feasibility of inline digital holography was also performed. Finally, a rabbit aneurysm model was developed in order to treat different aneurysm morphologies. This thesis presents a series of methods that can be used to study of the embolic risks of a novel aneurysm treatment with the potential to impact millions of lives.
Notlar:
School code: 0391
Tüzel Kişi Ek Girişi:
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(693111.1) | 693111-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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