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Overcoming the Limitations of Tissue Engineered Scaffolds for Dental Root Repair
Başlık:
Overcoming the Limitations of Tissue Engineered Scaffolds for Dental Root Repair
Yazar:
McCune, Jenna Rose, author.
ISBN:
9780438049567
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (59 pages)
Genel Not:
Source: Masters Abstracts International, Volume: 57-06M(E).
Advisors: Robert E. Baier Committee members: Rosemary Dziak; Anne Meyer.
Özet:
Major requirements of tissue-engineered scaffolds for any purpose are to demonstrate their initial sterility, and to demonstrate their ability to exchange nutrients/wastes while receiving sufficient interior oxygenation. In the special case of cell-growth scaffolds to be used for endodontic purposes, the biomaterial constructs must also be long and thin while remaining sufficiently porous and strong to allow cellular growth within often irregular and narrow root canals. This research evaluated the prospects that crafted narrow scaffolds of sintered, biodegradable Bioglass could initiate and sustain osteoblastic or odontoblastic ingrowth via interior channels introduced by sacrificial filaments of fibers and/or perforated tubing. The work confirmed that the high temperatures of the sintering process sufficiently sterilized the scaffolds to allow their immediate clinical use from sterile containers. The presence of an interconnectivity channel system via burn out of porous polypropylene oxygenator membranes allows for proper nutrient delivery to the infiltrating cells. Blackened carbon-coated scaffolds acted as a filter for the media, resulting in no nutrient delivery to the cells. The new white scaffolds did not filter the media but their high alkaline pH caused necrosis of all cells. Future work should be done to neutralize the pH by finding an appropriate volume to sample ratio to be able to overcome the initial pH flush.
Notlar:
School code: 0656
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
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XX(694126.1) | 694126-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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