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The Central Amygdala Corticotrophin-Releasing Hormone (CRH) Neurons Modulation of Anxiety-Like Behavior and Hippocampus-Dependent Memory in Mice
Başlık:
The Central Amygdala Corticotrophin-Releasing Hormone (CRH) Neurons Modulation of Anxiety-Like Behavior and Hippocampus-Dependent Memory in Mice
Yazar:
Paretkar, Tanvi, author.
ISBN:
9780355992700
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (31 pages)
Genel Not:
Source: Masters Abstracts International, Volume: 57-06M(E).
Advisors: Eugene Dimitrov Committee members: Lisa Ebihara; Charles McCormack; Carl White.
Özet:
The encoding, consolidation and retrieval of memories is a multifaceted process that depends strongly on the optimal level of arousal. Very high levels of arousal may trigger anxiety, which negatively impacts the memory processing by the brain. We investigated the role of CRH neurons in the central amygdala (CeA) for their capacity to modulate both, the anxiety-like behavior and hippocampus-dependent memory. First, we activated the CRH neurons in CeA using cre-activated excitatory DREADDs in CRH-cre mice. The activation of CeA CRH neurons increased the anxiety-like behavior in Elevated O maze (O-maze) and light-dark box (LDB). The activation of the CeA CRH also decreased Y-maze memory performance and the discrimination index in novel object recognition test (NOR). The inhibition of CeA CRH neurons with AAV-DREADD-Gi decreased the anxiety-like behavior in O-maze and increased discrimination index in the NOR. Next, we used a combination of retrograde cre virus injected in LC and cre-activated AAV- DREADD-Gs injected into the CeA. While the excitation of the CeA neurons that project to LC increased the anxiety-like behavior, the activation of the CeA projections to LC led to the opposite effect on memory performance. The behavioral and memory effects were accompanied by increased Fos expression in the LC region. Pretreatment with CRH1receptor antagonist antalarmin hydrochloride blocked the effects that were observed after the activation of the CeA projections to LC.
Our findings highlight the role of CeA CRH neurons not only as generators of anxiety but also demonstrate their role in the control of memory processing.
Notlar:
School code: 1489
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(694263.1) | 694263-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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