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Evaluation of the Prognostic Significance of AJCC Staging Guidelines in Lung Carcinoid Tumors
Başlık:
Evaluation of the Prognostic Significance of AJCC Staging Guidelines in Lung Carcinoid Tumors
Yazar:
Yoon, Ji Yoon, author. (orcid)0000-0002-8897-7144
ISBN:
9780438129351
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (25 pages)
Genel Not:
Source: Masters Abstracts International, Volume: 57-06M(E).
Includes supplementary digital materials.
Advisors: Michelle Kang Kim.
Özet:
Purpose: The American Joint Committee on Cancer (AJCC) Tumor Lymph Node and Metastasis (TNM) classification for lung cancer, originally designed for non-small cell lung carcinoma, is applied to staging of bronchopulmonary carcinoid tumors. The validity of the 8th Edition staging system for carcinoid tumors has not been assessed. In this study, we evaluated its prognostic accuracy using data from a large national population-based cancer registry.
Patients and Methods: Patients with typical and atypical bronchopulmonary carcinoids, diagnosed between 2000 and 2013, were identified from the National Cancer Institute's Surveillance, Epidemiology and End Results (SEER) registry. We used the Kaplan-Meier method and Cox regression to compare 10-year disease-specific survival (DSS) across stages.
Results: Overall, 4,645 patients with bronchopulmonary carcinoid tumors were identified. Survival analysis and adjusted analysis generally demonstrated worsening DSS with increasing TNM status and stage, across both typical and atypical carcinoids, with overlaps between adjacent subcategories. The combined stages (I vs II, II vs III, III vs IV) demonstrate clearer separation in survival outcomes. For typical carcinoids, stage I conferred 10-year DSS of 96.1% (CI: 94.9-97.0), in comparison with 84.6% (CI: 79.2-88.6) for stage II, 78.9% (CI: 73.8-83.2) for stage III, and 55.7% (CI: 47.0-63.6) for stage IV.
Conclusion: The combined stage categories of the 8th Edition AJCC TNM staging system provide useful information on outcomes for typical and atypical carcinoids. However, subcategories of the staging system demonstrate substantial overlap, suggesting further study and adjustment is required.
Notlar:
School code: 1734
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(694435.1) | 694435-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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