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Potassium and the Prebiotic Formation of Polypeptides
Başlık:
Potassium and the Prebiotic Formation of Polypeptides
Yazar:
Campbell, Thomas D., author.
ISBN:
9780438128156
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (196 pages)
Genel Not:
Source: Dissertation Abstracts International, Volume: 79-11(E), Section: B.
Advisors: Paul J. Bracher Committee members: Christopher K. Arnatt; Ryan D. McCulla; Jamie M. Neely; Brent M. Znosko.
Özet:
The intracellular enrichment of K+ (relative to Na+) by modern life is nearly as universal as the central dogma of biochemistry, and therefore is presumed to be a primordial feature of life. However, the role of these ions in the development of early life is unclear. We studied the impact of K+ and Na+ on simple organic reactions relevant to the origin of life---specifically, the hydrolysis and condensation of peptides. We found that K+ and Na+ affect the rate of peptide hydrolysis in an unexpected, substrate-dependent pattern. We also found that these ions differentially impact the yield for the condensation of amino acid via wet--dry cycling. These results raise the possibility that the ubiquitous selection for intracellular potassium over sodium observed in modern life developed early in evolution to optimize the kinetics of reactions of peptides.
Notlar:
School code: 0193
Tüzel Kişi Ek Girişi:
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(694532.1) | 694532-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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