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![Characterization of Organic Chalcone 17 Resistant Caenorhabditis elegans Mutant için kapak resmi Characterization of Organic Chalcone 17 Resistant Caenorhabditis elegans Mutant için kapak resmi](/client/assets/d79c3e4af2b6d196/ctx/images/no_image.png)
Characterization of Organic Chalcone 17 Resistant Caenorhabditis elegans Mutant
Başlık:
Characterization of Organic Chalcone 17 Resistant Caenorhabditis elegans Mutant
Yazar:
Melkonian, Tamar, author.
ISBN:
9780438100640
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (61 pages)
Genel Not:
Source: Masters Abstracts International, Volume: 57-06M(E).
Advisors: Alejandro Calderon-Urrea Committee members: Saeed Attar; Joseph Ross.
Özet:
Plant Parasitic Nematodes (PPNs) are a challenging problem in today's agriculture causing an annual loss of about 157 billion dollars (Li et al., 2015). Until recently, methyl bromide was the most used agent for controlling PPNs. However, methyl bromide is now not preferred because of its high toxicity (Li et al., 2015). This establishes a problem by losing a way to control these PPNs. In order to effectively kill these PPNs, Dr. Calderon-Urrea's laboratory used Caenorhabditis elegans (C. elegans) as a model organism and identified certain chalcones as effective nematicidal agents (Attar, 2011). Chalcones are organic chemical compounds found to be effective in killing the reference strain used in the ACU laboratory (PD4251) of C. elegans (Attar, 2011). For the purposes of this thesis the PD4251 strain, which contains the green fluorescence protein (GFP), is noted as the reference strain. Currently the lab has found three chalcones, 17, 25, and 30, that are effective in killing the reference strain, and although the mechanism behind the chalcones' mode of action is unknown, research in the lab suggests these three chalcones may target different biochemical pathways in the nematode.
Previously, Dr. Calderon-Urrea's laboratory identified a mutant strain, 17.1.2, of C. elegans that is resistant to chalcone 17 (Tamayo, 2016). The current research aims to further characterize this mutation using fluorescence staining techniques, coordination ability by using the WormTracker software analyses, genetic mapping, and further genetic screenings to identify additional chalcone mutants. The data shows the mutant having a significant difference in movement, speed, and distance traveled when compared to the reference strain.
Notlar:
School code: 6050
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(695369.1) | 695369-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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