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Phylogenetic analysis of plants with antibacterial activity reveals certain plant families relevant for antibiotic drug discovery
Başlık:
Phylogenetic analysis of plants with antibacterial activity reveals certain plant families relevant for antibiotic drug discovery
Yazar:
Prasad, Malini Anna, author.
ISBN:
9780438079120
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (62 pages)
Genel Not:
Source: Masters Abstracts International, Volume: 57-06M(E).
Advisors: Jeanmarie Molina.
Özet:
Antibiotic development and bacterial mechanisms of antibiotic resistance are productive areas of research today, as a result of emerging infectious diseases and an increased prevalence of antibiotic resistant pathogens. Ethnomedicinal plants have potential as a source of natural antibiotics that may aid in combating antibiotic resistance. Plants are rich in a wide variety of secondary metabolites that have been found in vitro to have antimicrobial properties. Some plant families have been used in traditional medicine disproportionately over other families, and these may be potential sources for antibiotic drug discovery. This current study aimed to reconstruct the phylogeny of plant species that have shown antibacterial activity in the scientific literature. Antibacterial mechanisms of action were mapped on the phylogeny to determine if certain plant families exert similar mechanisms due to similar phytochemistry. Phylogenetic results highlighted five plant families (Fabaceae, Lamiaceae, Lauraceae, Myrtaceae, Zingiberaceae) that exert similar mechanism of antibacterial activity and associations between phytochemistry and antibacterial targets were found. In Myrtaceae, anti-quorum sensing properties can be linked to flavonoid downregulation of virulence factors. In Lamiaceae, Fabaceae, Lauraceae, and Zingiberaceae bacterial cell membrane and/or cell wall disruption are associated with lipophilic terpenes and membrane permeabilizing phenols. Similar phytochemicals seem to exist in phylogenetically unrelated lineages, demonstrating convergent evolution. Moreover, due to variations in the phytochemical composition of bioactive extracts, as well as synergistic effects from the mixture of constituents, it is possible that multiple secondary metabolites may be responsible for the observed antibacterial activities. The present study highlights the utility of using phylogeny in drug discovery, revealing the value of particular plant families as promising leads towards novel antibiotic drug development.
Notlar:
School code: 0198
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(696255.1) | 696255-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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