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Quantitative Analysis of Mineral/Matrix to Evaluate Genetically Altered Bone with Infrared Spectroscopy and X-Ray Spectral Imaging
Başlık:
Quantitative Analysis of Mineral/Matrix to Evaluate Genetically Altered Bone with Infrared Spectroscopy and X-Ray Spectral Imaging
Yazar:
Yadav, Sunil Balasaheb, author.
ISBN:
9780438127500
Yazar Ek Girişi:
Fiziksel Tanımlama:
1 electronic resource (113 pages)
Genel Not:
Source: Masters Abstracts International, Volume: 57-06M(E).
Advisors: Harry Tibbals Committee members: Kyungsuk Yum.
Özet:
This thesis focuses on the characterization of bone with the help of Fourier Transform Infrared Spectroscopy and Energy Dispersive Spectroscopy. Such analysis of the physics and chemistry of biomaterials is vital to resolve problems in life science of bone-related diseases and disorders. Material characterization can help in the understanding of disease mechanisms and lead to useful drugs and other treatments. In this thesis, I have used bone materials produced by groundbreaking research at UT Southwestern Research Center and Texas Scottish Rite Children's Hospital to establish that idiopathic clubfoot (Talipes equinovarus) is associated with the Follistatin 5 gene. We studied healthy wild-type laboratory rats in comparison with genetically modified rats, called knock-out type, in which function of the Follistatin 5 gene was controlled with genetic engineering. We were able to identify significant differences in mineral and matrix composition of bone despite considerable variability in the samples. For mid-diaphysis of bone, matrix content was reduced in the knockout compared to the wild-type, leading to the increased mineral to matrix ratio in the knockout.
Notlar:
School code: 2502
Konu Başlığı:
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Yer Numarası | Demirbaş Numarası | Shelf Location | Lokasyon / Statüsü / İade Tarihi |
---|---|---|---|
XX(696670.1) | 696670-1001 | Proquest E-Tez Koleksiyonu | Arıyor... |
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